The returning a null value from a Web Service method, which is defined in CXF using Document/Literal Wrapped style, an NPE occurs within Mule. See the description at
http://www.nabble.com/Mule-2.0.1-CXF-WSDL-First-tt17877561.html
for another user who probably also faces this problem (null pointer in org.apache.cxf.jaxws.interceptors.WrapperHelper $ReflectWrapperHelper.createWrapperObject(WrapperHelper.java:278)".
The NPE is caused by org.apache.cxf.message.MessageContentList.getContentsList() returning null (MessageContentList.java:45). In org.apache.cxf.jaxws.interceptors.WrapperHelper $ReflectWrapperHelper.createWrapperObject(WrapperHelper.java:278) the returing null value is dereferenced.
The original null value which is used originates from MuleInvoker.java:131